As a global, innovation-driven biopharmaceutical company, AstraZeneca has a key contribution to make through the discovery, development, manufacturing and commercialisation of medicines for six important areas of healthcare: cancer, cardiovascular, gastrointestinal, infection, neuroscience and respiratory and inflammation. We encourage you to read the privacy policy of every website you visit.You have selected a link that will take you to a site maintained by a third party who is solely responsible for its contents.We’re targeting the underlying biological drivers of cancer by focusing on four different scientific platforms: Immuno-Oncology, Tumour Drivers and Resistance, DNA Damage Response, and Antibody Drug Conjugates.Our patient-centric approach focuses on 1) identifying and treating patients earlier in the course of their disease with curative intent; and 2) supporting relapsed and refractory patients by tackling primary or acquired resistance.Activating the body’s own immune system to help fight cancerThe great advance of personalised healthcare, in oncology, has been the realisation that some tumours are driven by individual genes. We’re expanding our presence across geographies to deliver timely treatments to patients in the US, UK, Italy, France, Germany, Spain, Japan, and China.Targeting the genetic mutations and resistance mechanisms that enable cancer cells to evade treatment, survive, and proliferateWe’re concentrating on biomarker-driven indications to dramatically improve five-year survival in five tumour types, including ovarian cancer and non-small cell lung cancer (NSCLC).Be among our employees who continue to make us an innovation-driven company that stands firmly among the world’s leaders in biopharmaceuticals.and help us deliver life-changing medicinesClick ‘cancel’ to return to AstraZeneca’s site or ‘continue’ to proceed.Targeting the DNA repair process to block cancer cells’ ability to reproduceGenomics is the foundation of what science can do to understand the causes of disease and develop new medicines.We’re concentrating on four scientific platforms that we believe show the greatest potential for yielding effective medicines for cancer patients.Our medicines are approved in individual countries for specific uses. The deal will not affect 2020 earnings forecast, AstraZeneca said.Analysts have previously said the group needed to be mindful of indebtedness and ability to pay dividends after a similar deal last year with financial commitments to Daiichi of as much as $6.9 billion.That deal also involved an ADC, targeting the HER2 protein seen in many breast cancers.
Even as R&D continues to push boundaries in how we understand and fight cancer, there is still more to do. Homing in on the cells that produce too much of the protein allows the treatment to deliver selective chemotherapy to certain areas, rather than subjecting the whole body to the treatment.The deal will give AstraZeneca a slice of the global sales of the treatment, as the two companies have agreed to partner up to develop and then commercialise DS-1062. In a further boost to AstraZeneca's oncology unit, two of its on-market therapies, one for lung cancer and another for blood cancer, won regulatory endorsements for expanded use in Europe.AstraZeneca shares were roughly unchanged at 8,644 pence by 0917 GMT."We see significant potential in this antibody drug conjugate in lung as well as in breast and other cancers that commonly express TROP2," AstraZeneca Chief Executive Pascal Soriot said, referring to a protein found on some cancer cell surfaces.London-listed AstraZeneca said on Monday it would pay $1 billion upfront to Daiichi in staggered payments for an experimental drug called DS-1062, which belongs to a promising class of therapies called antibody drug conjugates (ADC).The drugmakers have also been in talks over supply of the British company's coronavirus vaccine in Japan.Britain's AstraZeneca will pay up to $6 billion to Japan's Daiichi Sankyo under the drugmakers' second multi-billion dollar oncology collaboration to develop and market a niche type of targeted cancer treatment.An anti-TROP2 ADC called Trodelvy developed by Immunomedics won U.S. regulatory approval in April to treat an aggressive type of breast cancer, while Chinese firms Kelun Group and Bio-Thera Solutions are also working on TROP2-based biotech drugs.JP Morgan analysts said the drug could bring $1 billion or more in annual sales, adding that since AstraZeneca's upfront commitments are spread over three years, it could still keep previous dividend cover commitments.Log in with your social accountFurther payments would depend on regulatory and sales milestones being achieved.
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